Bromadiolone is a rodenticide meant to kill rats and mice.
Bromadiolone is a potent anticoagulant rodenticide.
It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist.
It is a super-warfarin compound because of higher potency and nd prolonged anticoagulation probably due to:(i) greater affinity for vitamin K(1)-2,3-epoxide reductase; (ii) ability to disrupt the vitamin K(1)-epoxide cycle at more than one point; (iii) hepatic accumulation; and (iv) unusually long biological half-lives due to high lipid solubility and enterohepatic circulation.
Bromadiolone elimination kinetic is of a two-compartment model with a . . .
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