Difethialone is an anticoagulant used as a rodenticide. It is a second generation rodenticide.
In rodents, difethialone is characterised shows a short half-life in blood and a longer half-life in liver
It is predominantly eliminated unchanged through the fecal route.
Typical features of poisoning include:
Minor poisoning: coagulation disturbance detected only by laboratory analyses;
Moderate poisoning: coagulation disturbance resulting in hematomata, hematuria, blood in feces or excessive bleeding from minor cuts or abrasions, gum bleeding;
Severe poisoning: retroperitoneal hemorrhage, severe GI bleeding, cerebrovascular accidents, massive internal bleeding resulting in shock.
Symptoms are severe in anaemia or liver disease . . .
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