Clinical Pharmacology
Atenolol is more water soluble than propranolol
Atenolol is a synthetic, beta1-selective (cardioselective) adrenoreceptor blocker
Hydrophilic β-blockers may have membrane-stabilizing activity though much higher concentrations
It has no intrinsic sympathomimetic activities.
At higher doses atenolol inhibits beta2-adrenoreceptors chiefly located in the bronchial and vascular musculature.
Oral absorption is rapid but incomplete( approx. 50% of an oral dose is excreted unchanged in the feces)
Atenolol undergoes little or no hepatic metabolism, and most of systemic portion is eliminated primarily by renal route.
The elimination half-life of oral atenolol is approximately 6-7 hours . . .
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