- Flumioxazin is an herbicide of the N-phenylphthalimide class that is currently used for pre- and
post-emergence control of susceptible weeds - The herbicidal mechanism of flumioxazin is the inhibition of protoporphyrinogen oxidase (PPO), the enzyme responsible for converting protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll in plants. This mechanism of action also appears to be involved in some of the toxicological effects observed in mammals. It is likely to be involved, at least in part, in hematological and developmental effects. Inhibition of PPO leads to the accumulation of porphyrins in susceptible . . .
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