Imidacloprid is the most well-known and widely used representative of the neonicotinoid insecticides.
Imidacloprid is an agonist of the nicotinic acetylcholine receptor (nAChR) at the neuronal and neuromuscular junctions in insects and vertebrates.Prolonged activation of the nAChR by imidacloprid causes desensitization and blocking of the receptor, and leads toclinical signs characteristic for nicotine intoxication, such as incoordination, tremors, spasms and respiratory difficulties (California Environmental Protection Agency 2006; Gervais et al., 2010).
Ordinarily, the binding affinity of imidacloprid at the nicotinic receptors in mammals is much less than that of insect nicotinic receptors.
Imidacloprid is moderately toxic if ingested . . .
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