Although metronidazole is generally safe and well-tolerated in usual therapeutic doses taken for short periods of time, higher doses (like in overdose) or typically after prolonged exposure (> 3wks)-though it can occur at low cumulative doses-has been infrequently associated with significant neurotoxicity including peripheral neuropathy, symptoms of central nervous system dysfunction like ataxic gait, dysarthria, seizures, and encephalopathy collectively termed as “metronidazole induced encephalopathy (Sørensen et al.,2020).
Metronidazole induced encephalopathy characteristically affects the dentate nuclei but may also involve the brainstem, corpus callosum, subcortical white matter, and basal ganglia. While the clinical symptoms and neuroimaging . . .
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