Tetracycline group of drugs include tetracycline, chlortetracycline, methacycline, demeclocycline, doxycycline, lymecycline, minocycline and oxytetracycline.
All of them are bacteriostatic drugs with a similar spectrum of activity. Currently, one of the important indications for the use of tetracyclines is typhus fevers caused by Rickettsiae (group of bacterial diseases spread to humans by fleas, lice, and jiggers). Doxycycline is the drug of choice for this indication.
The group has similar adverse events, but the severity may be more with some members. For example, demeclocycline use has significant risk of photosensitivity reactions and nephrogenic diabetes insipidus.
Tetracyclines, except minocycline and doxycycline are excreted . . .
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