Chlorfenvinphos is a chlorinated organophosphorus ester manufactured as an insecticide and acaricide. Therefore, it is a direct-acting cholinesterase (ChE) inhibitor since it does not require metabolic activation to yield anti-ChE activity in comparison to organothioates.
Occupational exposure may occur through inhalation or skin contact with treated animals, and the general public may be exposed through groundwater leaching or contact with contaminated soils. However, ingestion remains the commonest route of exposure to chlorfenvinphos.
Clorfenvinphos, like other organophosphate insecticides, exerts its toxic effects primarily through the inhibition of the enzyme acetylcholinesterase (AChE), which is responsible for breaking down the neurotransmitter . . .
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