Toxicology
The most relevant imidazothiazoles for veterinary use are: levamisole,Tetramisole and butamisole.
The anthelmintic activity of tetramisole, a racemic mixture, resides in the L-isomer, levamisole. It is commonly used veterinary animals to treat nematode infections; it has no activity against flukes and tapeworms.
Levamisole has immunostimulant effects at dosage rates higher than those used for anthelmintic activity.
Imidazothiazoles are nicotinic anthelmintics that interfere with neuromuscular coordination by acting agonistically at nicotinic acetylcholine receptors.
Their anthelmintic activity is mainly attributed to their ganglion cholinomimetic activity. This stimulation first results in sustained muscle contractions, followed by a neuromuscular depolarizing blockade . . .
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