Flumetsulam (Â triazolopyrimidine sulphonamide structure) targets acetolactate synthase (ALS), an enzyme critical for branched-chain amino acid biosynthesis in plants. However, it may show antimicrobial activity because ALS is also present in some microorganisms.
It is rapidly but incompletely absorbed in mice and rats. Approximately 20-35% of the dose remains unabsorbed and is excreted in the feces (National Center for Biotechnology Information)
Whatever is absorbed is rapidly excreted mostly unchanged in urine with a urinary half-life of approximately 5-7 hr.
ALS-inhibiting herbicides are generally considered to be poorly toxic because the target enzyme in plants does not . . .
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