Cyhalofop‑butyl is an aryloxyphenoxypropionate herbicide, widely applied post‑emergence in agriculture for weed control in rice and aquatic environments. Its primary mode of action is inhibition of acetyl‑CoA carboxylase, a key enzyme in plant fatty acid biosynthesis.
Acute toxicity studies in mammals show low hazard potential: oral LD₅₀ in rats exceeds 5,000 mg/kg, with no evidence of irritation or sensitisation (EFSA, 2015). Toxicokinetic studies reveal rapid and extensive absorption (>90%), uniform distribution, and sex‑related differences in peak plasma levels (faster in females). Metabolism occurs via hydrolysis to cyhalofop acid, which is conjugated and rapidly . . .
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