Sulcotrione is a herbicidal agent in the triketone family. Sulcotrione herbicides are used for weed control in maize and flax crops.
In mammalian metabolism studies, sulcotrione was rapidly and completely absorbed and excreted unchanged after oral administration excreted mostly via the kidney, after minimal biotransformation (EFSA, 2008). According to the case series by Boels et al. (2013), limited toxicokinetic data showed that sulcotrione undergoes slow elimination.
Sulcotrione shows low toxicity via the oral, dermal, or inhalation route. Animal toxicity studies in the rat reported acute median lethal dose (LD50) of >5000 mg/kg. It may cause sensitisation by skin . . .
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