The compound controls weeds by reducing levels of three branched-chain aliphatic amino acids, isoleucine, leucine, and valine, by inhibiting aceto-hydroxyacid synthase, an enzyme common to their biosynthetic pathway.
Imazethapyr was of low acute toxicity after oral, dermal, and inhalation exposure. The oral LD50 in rats and rabbits was greater than 2000 mg/kg bw. However, despite low lethality, in vitro studies on zebrafish liver cell lines indicated that
imazethapyr can produce cytotoxicity, inhibit mitochondrial function, and impair cell membrane function, which might be seen if exposure is prolonged (BenchChem Technical Support Team, 2026).
In animal studies, orally administered . . .
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