Pyroxsulam has low acute oral (LD50 >2000 mg/kg bw), dermal (LD50 >2000 mg/kg bw), and inhalational (LC50 = 5120 mg/m3) toxicity in rats. It is not a skin and eye irritant in rabbits, but was a moderate to severe skin sensitiser in the guinea pig maximisation test (USEPA, 2008;Australian Pesticides and Veterinary Medicines Authority, 2008).
There was minimal toxicity observed in the repeat-dose toxicology studies via the oral and dermal routes of exposure.
In the kinetics study in rats, pyroxsulam was rapidly absorbed and excreted via the urine and feces within 24 hours post . . .
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